Suzanna lived in the Crown Colony of Massachusetts with Aidan in the mid 18th century. Before the American Revolution, the young couple were trying hard to have a child, and were unsuccessful until their third attempt. The preacher at the local church, Reverend Herring, called the Waite family out during a service, claiming that the reason she had been miscarrying was because she was being punished by God. Aidan later got into a fight with the Reverend, who he believed to covet Suzanna, and the tension reached a breaking point when he punched the preacher in the face.
After Aidan went off to fight in the American War of Independence and did not return, Suzanna believed him to be dead, until she discovered him many months later as a vampire, feeding off of chickens in their barn. Horrified that their neighbors would think they were consorting with the Devil, she kept her husband hidden away in their home, feeding him with her own blood. Despite her husband's transformation, Suzanna still loved Aidan, as she could sense that he was still the Aidan that she had always known. She makes Aidan promise her that he would find love again someday after she died.
After Aidan's vampirism was discovered by the other colonists, Reverend Herring, believing Suzanna to be guilty of witchcraft, lashed her to a rock and let her sink into a river.Upon discovering what had happened, Aidan went on a murderous rampage of retribution, killing Herring and several others involved in his wife's 'trial'.
Unbeknownst to Aidan, Bishop retrieved her from the river a short time later, turning her into a vampire and resurrecting her. Overwhelmed by hunger, she feeds on the first human she encounters, which she discovers to her horror is her son, Isaac.
A woman shows up in the present day coming out of a cab in the finale of Season 3 bearing a striking resemblance to Suzanna.
Aidan catches a glimpse of Suzanna at Kat's faculty mixer, but when he goes outside to look for her, she is nowhere to be found.
Aidan continues to have visions and dreams about his long-lost wife, until she appears to him on his doorstep. It is then that Aidan discovers Suzanna is a vampire, as she is unable to enter the house.
Aidan and Suzanna try to catch up with one another, with Aidan asking her questions about her life over the last 200+ years, though Suzanna seems reluctant to tell him much, though she lies to him that Isaac lived a long and happy life, and died a grandfather.
A few days later, Aidan goes to visit Suzanna in her hotel room, ironically the hotel Aidan frequently visited in Season 2. He asks to come in, though it seems to take Suzanna a moment to process what he's asked. She welcomes Aidan in, though when she turns to close the door behind him, she's seen to be holding a colonial time stake shaped like a cross. Her expression reveals she was expecting someone else besides Aidan. They move into the living quarters, and almost immediately Aidan begins to ask her questions of the past, and why she never tried to start a life with him. Suzanna hesitates, then tells Aidan that Bishop would have rather had a son over a daughter, and didn't think her worthy of Aidan, and she also couldn't believe it when she heard that Bishop was dead, not until she found out Aidan killed him. At that note, Aidan continued to question Suzanna about her past, but she only told him that the past should Stay in the past.
Later that night, Suzanna has just taken a shower, and she is walking back toward the bed with a look of dread on her face. We then see her take off her robe, and a flashback begins to take place. We go back to the days after she was turned into a vampire, and is roaming the forest. She is only stopped when a small boy runs past her, the smell of his blood forcing her to the ground. At this point, Suzanna could die at any time from lack of blood, and begins to hallucinate of Aidan. He tells her to feed just his one time for her, resulting in her using her vampire speed to run after the small boy. We then are taken back to the present, where we see a saddened Suzanna pull a whip from over her bed. It seems that in grief of this certain memory, each night she whips herself. Then, we are taken back to the past, where a young Suzanna takes down the small boy and drains him of his blood. Though it turns out the boy was her own son Isaac. She is then horrified and shocked that she just killed her own son. Once again we are taken back to the future, where Suzanna continues to whip herself. It is then when Bishop shows up to see Suzanna holding to dead body of her son. Suzanna begs Bishop to turn Isaac, but he refuses saying he couldn't curse a child to damnation. So in turn she begs him to kill her, and he again refuses, telling Suzanna after this life, they don't get another chance. It is assumed she then buries the body of her dead son.
While Kenny and Aidan are gone from one of the new Vampire 'Blood Dens' Suzanna gets into the club, where she stakes all the vampires inside. It is unknown as of yet why she is doing this, or if she intends to kill Aidan and or Kenny, as they are technically her family.